Authors : Y. W. There, V. S. Wadhai and P. R. Bhandari
Page Nos : 358-361
Description :
Abstract:
Antibiotic resistant pathogens constitute an important and growing threat to the public health. Antibiotic resistance occurs when a microbe acquires a gene, which allows the microbe to inactivate the antibiotic or otherwise nullify its antimicrobial activity. Staphylococci are widespread pathogens and are frequently associated with hospital-acquired infections. Healthcare-associated methicillin-resistant S. aureus (MRSA) is a major cause of nosocomial infections worldwide, with significant attributable morbidity and mortality in addition to pronounced healthcare costs. Many hospitals struggle with increasing amounts of MRSA, which are \"multi-resistant\" against all beta-lactam antibiotics. Often, applicable antibiotics for treatment are only glycopeptides like vancomycin. The main objectives of this study was to find out the antimicrobial susceptibility pattern of S.aureus isolates, the prevalence of methicillin resistant S.aureus and demonstration of Vancomycin resistance among MRSA strains Method: A total 139 clinical samples like pus, sputum and burn wounds are screened for the isolation of S.aureus strains. The pure isolates of coagulase positive S.aureus were tested for antimicrobial susceptibility by using standard methods. Results: Out of 139 clinical specimens 100 samples were found to be coagulase negative S.aureus. High resistance was observed against , penicillin, erythromycin and tetracycline. High sensitivity was recorded against amikasin, chloramphenicol & Gentamycin. Of the isolates 76 isolates were methicillin resistant S.aureus (MRSA). Vancomycin resistant among MRSA isolates was found 14%. Conclusion: Our study emphasizes the need for continuous monitoring of the antimicrobial susceptibility pattern of S.aureus isolates including MRSA for the selection of appropriate therapy. In Chandrapur , from the present findings it appears that the spread of MRSA in community is very high and the vancomycin which is the last choice for the treatment MRSA strains also shown resistant. So there is need of high alert in hospital settings and need of continuous monitoring and surveillance to control resistance.
Keywords: MRSA, VRSA, Antibiotics and Oxacillin.
