Authors : N. Narkhede1 , S. Deo2 , F. Inam3
Page Nos : 949-955
Description :
Wound is actually the disruption of cellular and anatomical discontinuity of tissue.In the present work five spices Sygyzium aromaticum(cloves), Cinnamomum zeylanicum( dalchini), Cinnamomum tamala (tejpatta),Myristica fragrans(nutmeg) a herb Ocimum sanctum (tulsi) were studied to see the effect of their common constituent Eugenol on the wound healing activity. Excision and incision wound models and dead space in Sprague Dawley rats were used to study complete epithelisation time, wound contraction , histopathological studies and tensile strength of wounds. The animals were divided into separate groups with 6 animals in each group. The time taken for wound contraction and complete epithelisation by various spices was significantly (p<0.05 to p<0.001) less as compared to control. Mean tensile strength of the 5 mentioned spices were significant greatly (p<0.05 – p<0.01) after 16 days when compared with control animals. The methanolic extract of all the above spices showed better granulation tissues, early and complete epithelisation and better tensile strength compared to control.
