Authors : Sushil B Kapoor, Naziyanaz B Pathan , Nilesh V Gandhare c, Parvez Ali
Page Nos : 64-76
Description :
An expeditious, efficient and eco-friendly method for one pot synthesis of novel pyrimidine-chalcone hybrids under ultrasound irradiations using Alumina supported Na2CO3 as a green catalyst has been developed and reported. The present method is safe, mild and effective affording excellent yields of novel pyrimidine-chalcone hybrids within shorter reaction times. All the synthesized compounds were characterized using melting point, IR, 1H-NMR, 13C-NMR and Mass spectral study. Newly synthesized compounds were screened for their in vitro antibacterial activities against S. abony, S. epidermidis and E. coli microorganisms. Molecular modelling studies viz., Lipinski rule of five, drug likeness, drug scores, toxicity profiles and other physico-chemical properties of drugs were performed using Molinspiration and Osiris softwares available online and verified experimentally.
