Authors : S. A. Kamble
Page Nos : 273-276
Description :
Phthalazine and its derivatives are compounds with heterocyclic rings which have wide range of applications in medicinal and synthetic chemistry. They exhibit multiple pharmacological activities. Phthalazine is used to lower blood pressure in human. Evaluation of the antimicrobial potential of the newly synthesised compound is an important step in the development of the drug that may be effective against microbial infections and less toxic to the host. Phthalazine derivatives have attracted the attention because of their therapeutic value. The number of phthalazyl hydrazine derivatives are apparently true hypotensive agents of mild potency and reasonable safety. Therefore, researcher has conducted study of synthesis and biological activities of these compounds. The title compounds were synthesised as per the scheme and properly analyzed. Later they were subjected to antimicrobial screening. The results of antimicrobial screening indicates that the phthalhydrazide, it’s disodium salt, 2,3-Dihydrazidophthalhydrazide exhibited good antibacterial activity against both types of bacterial species. Thus, phthalazine derivatives have attracted the attention because of their therapeutic value. These are true hypotensive agents of mild potency and reasonable safety. Therefore, researcher has conducted study of synthesis and biological activities of phthalazine derivatives. Some of them have great and promising medicinal value.
