Authors : M. N. Narule and S. B. Rewatkar
Page Nos : 316-319
Description :
Abstract:
Synthesis of 4-amino benzylidene acetophenone 1 was prepared by condensing acetophenone with 4-amino aldehydes. 4-amino benzylidene acetophenone react with 4-hydroxy aldehyde to give 4-Arylidene (4-hydroxy phenyl) benzylidene acetophenone 2 combine with substituted anilines gives 4-Arylidene phenyl (4-amino benz) benzylidene acetophenone 3. 4-Arylidene phenyl (4-amino benz) benzylidene acetophenone undergo cyclization with sulpher and iodine gives 7-(4-Arylidene benzylidene acetophenones) substituted phenothiazine 4a-j. All these reaction are carried out in borosil beaker under microwave irradiation in microwave oven. The structural elucidations of these compounds were done on the basis of chemical and structural data. The antibacterial activity of these compounds have also been screened and found to be effective against gram +ve and gram –ve bacteria.
Keywords; Acetophenones, phenothiazine, aniline, microwave.
