Authors : P. Mahatme, I. Apte and S. Kotwal
Page Nos : 286-296
Description :
Abstract
One of the most common infertility disorders in women with ancient records is polycystic ovary syndrome (PCOS). PCOS is a multifaceted, complex condition which apart from infertility might often accompany abnormalities like insulin resistance (IR), Obesity, predisposition to Cardiovascular disease (CVD), Hypertension, Type 2 diabetes mellitus (T2DM), Dyslipidemia, non-alcoholic fatty liver disease (NAFLD) and overall metabolic dysfunction. The definite route behind prevalence of these disorders in women suffering from PCOS is still unclear. The present study attempts to investigate prevalence of oxidative stress in women of reproductive age suffering from PCOS and NAFLD, confined to central India population. We here conclusively demonstrate through biochemical and metabolic evaluation of enrolled patient population that oxidative stress could be a risk factor responsible for progression of PCOS into NAFLD in women of reproductive age. Compared with age, weight and BMI matched 47 healthy women volunteers, 63 PCOS and 51 NAFLD subjects demonstrated a significantly altered metabolic, hormonal and redox balance. PCOS and NAFLD patients showed significantly reduced serum antioxidant capacity through depletion of overall reducing power of serum, decreased glutathione reductase, SOD and CAT levels and elevated lipid peroxides.
Keywords: Polycystic ovary Syndrome, obesity, oxidative stress, SOD, CAT.
