Authors : R.P.Deshmukh* & B.N.Berad
Page Nos : 283-289
Description :
Synthesis of 3,4,5-tri-substituted 1,2,4-triazoles involving one step method has
been developed. These have been obtained by the self cyclo-condensation of (2E)-Nphenyl-
2-[(2E)-3-phenyl-1(arylamino)prop-2-en-1ylidene]hydrazine carbothioamide in
refluxing alcohol medium for one hour. The condensation occurs with the evolution of
H2S gas. The various hydrazine carbothioamide were synthesized by carrying out the
condensation of N-aryl-cinnamanilide and 4-phenyl thiosemicarbazide in chloroform
medium. The structures of 3,4,5-tri-substituted 1,2,4-triazoles have been established
on the basis of spectral studies including I.R., P.M.R., 13C N.M.R. and Mass
spectrometry. The 1,2,4-triazoles are further converted into their 1-acetyl derivatives by
treating them with glacial acetic acid and acetic anhydride in 1:1 ratio. These
compounds were evaluated for their in vitro antimicrobial activity.
