Authors : Ganvir K. S.
Page Nos : 158-161
Description :
Histopathological side effects on thyroid –pituitary axis was investigated. Gossypol a “China pill”(C30H30O8) is phenolic compound isolated from seed of cotton plant (Gossypium species).In 1972 a Chinese scientist isolated “Gossypol acetic acid” as a male antifertility compound and tested its antifertility effects in laboratory animals, primates and man . There are differences of opinion on toxic effects of Gossypol. Further investigations are required to determine side effects of this drug on thyroid and pituitary gland.
In present investigation male received Gossypol 20mg/kg B.W./day for 7 weeks and another group received 30mg/kg B.W./day for 5 weeks. Thyroid gland of treated animals showed no significant changes in its histology. Secretory epithelial cells and C cells (parafollicular cells ) showed no significant changes after the treatment. Gossypol induced no changes in TSH cells of anterior pituitary gland. Therefore it is concluded that Gossypol has no histopathological side effects on thyroid –pituitary axis.
