Authors : MONAL VELANGI, SUBHADRA MANDALIKA AND SURENDRA SHUKLA
Page Nos : 244-246
Description :
Prevalence of knee osteoarthritis (OA), a degenerative joint disease with cartilage degeneration and inflammation; and vitamin D deficiency are observed to rise in India. However, the association between vitamin D with Knee OA is less explored. Hence, present study was aimed at assessment of vitamin D status, inflammatory markers and pain in early Knee OA. Fifty adult early Knee OA patients (30-65years) were selected from K.J. Somaiya Hospital and Research Centre, Mumbai using purposive sampling technique. They were assessed for serum vitamin D status (serum 25 (OH) D, serum calcium, phosphorus and alkaline phosphatase -ALP), inflammation (erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) and pain (Visual Analogue Scale -VAS). Data was analysed using SPSS 16.0. 86% of the participants showed low Vitamin D status (< 30 ng/ml). Grade 2 Knee OA patients showed significantly higher CRP levels than grade 1 (p<.01). A negative correlation was observed between serum vitamin D level and the Knee OA grade and CRP. Moreover, serum vitamin D was positively correlated with ESR, serum calcium, phosphorus and ALP levels. A highly significant negative correlation between serum Vitamin D and pain score (p≤ .001) indicates the positive effect of vitamin D on pain. Results of this study indicated that early Knee OA patients are at the risk of vitamin D deficiency and supplementation with the anti-inflammatory nutrient vitamin D would be beneficial to reduce pain, inflammation and arrest disease progression in the Knee OA patients.
Key words: Knee osteoarthritis, Vitamin D, C-reactive protein, Inflammation
