Authors : D. V. Awale
Page Nos : 240-243
Description :
Acylation of m-cresyl methyl ether with succinic anhydride in presence of anhydrous aluminium chloride gave β-(2-methyl-4-methoxy) benzoyl propionic acid as a major product which on Clemmensen reduction furnish 4-(2-methyl-4-methoxyphenyl) butyric acid. Polyphosphoric acid cyclization of above acids yielded 5-methyl-7-methoxy-1-tetralone and 5-methoxy-7-methyl-1-tetralone which are useful as intermediates in the synthesis of many natural products such as terpenes, sesquiterpenes etc.
Keywords: Acylation, m-cresyl methyl ether, tetralone.
