Authors : Ruchi Wasnik, Vimal Dakhane
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Description :
Pathogenicity of the gram negative bacteria depends on the amount of autoinducer n-acyl homoserine lactone (AHL). Reduction in AHL could interfere with virulence to lower the infection. The halogenated furanone, 4-bromo-5-(bromomethylene)-3-(1′-hydroxybutyl)-2(5H)-furanone obtained from red macro alga Delsia pluchra showed structural similarity to that of AHL and thereby competitively inhibited AHL binding to its receptors. To identify compounds that are structurally similar to halogenated furanones literature survey has been performed on some plants and fungal species having known antibacterial activity. GC-MS and related analysis data reveled the potential species having furanone compounds in their extracts. The study done here uses online available cheminformatics tools (ChemMine) to identify furanone compounds structurally similar to 4-bromo-5-(bromomethylene)-3-(1′-hydroxybutyl)-2(5H)- furanone. This study suggests, a novel compound 2,5-dimethyl-4-hydroxy-3(2H)-furanone obtained from Ananas comosus as a potential candidate for reducing AHL levels. Both the compounds are found to be structurally similar and thus 2,5-dimethyl-4-hydroxy-3(2H)-furanone could be a potential quorum quencher which can ultimately inhibit bacterial virulence.
