Authors : Snehal Dighade, Jayashree Tirpude, Sapna Marbate, Gulmohar Patle, Smita Humane
Page Nos : 89-99
Description :
Cancer can be develop in almost any organ or tissue, such as the lung, colon, breast, skin, bones or nerve tissue. The chemotherapeutic drugs Cisplatin (Cl2H6N2Pt), the antineoplastic compounds in the class of alkylating agent used for the treatment of different kinds of cancer together with other chemotherapeutic agents. Toxic effect of Cisplatin on thyroid gland by evaluation of thyroid hormones (T3 and T4), pituitary hormone (TSH) were studied. The total body weights of all the animals treated with daily 2.5 and 5 mg/kg BW/ for 15 days with all the two drugs showed significant decrease in body weight (P < 0.05, P < 0.001). The total thyroid weight of all the animals treated with daily 2.5 and 5 mg/kg BW for15 days showed a significant increase in thyroid weight (P < 0.05, P < 0.001) as compared to control animals. A significant decrease in mean T3 (triiodothyronine) and T4 (Thyroxine) levels after Cisplatin, treatment is observed, however, with simultaneous significant increase in mean TSH (Thyroid stimulating hormone) levels, when compared to Vehicle-treated control. In the present study, it is observed that Cisplatin manifested more severe effects as evident by variability in the “types of cancers”.
