Authors : . A. Fulzele, Asifa Qureshi and V A. Fulzele
Page Nos : 78-83
Endophytes are organisms associated with plant tissues that are less explored ecological niche of novel fungi and bacteria. Such organisms are rich sources capable of producing bioactive metabolites, having immense pharmaceutical significance. Azadirachta indica is an evergreen tree with ethno-medicinal properties. In this investigation, an attempt has been made to isolate endophytes from different tissues of A.indica such as stem, leaf and bark. An endophyte identified as Fusarium decemcellulare isolated from leaf tissues, this endophytic fungus showed capacity of lovastatin production when subjected to solid state fermentation. The inhibitory effect of lovastatin extract from this endophytic Fusarium sp. on the growth of Sacchromyces cerevisiae was studied.