Authors : Y. K. Meshram, S. B. Rewatkar, G. R. Nimbarte and A. R.Gaurkar
Page Nos : 390-392
Description :
Abstract:
P. Biginelli in 1893 reported the synthesis of functionalized 3,4-dihydropyrimidin-2(1H)-ones (DHMPs) via three component condensation reaction of an aromatic aldehyde, urea and the ethyl acetoacetate. The yields of the dihydropyrimidinones obtained via this novel protocol are significantly higher than those utilizing the conventional ethanol / HCl method. A simple and economic synthesis of 3,4-dihydropyrimidin-2(1H)-ones by using phosphorus pentaoxide. The phosphorus pentaoxide can be converted into the phosphoric acid. The phosphorus pentaoxide has been found to be mild and efficient reagent for the synthesis of dihydropyrimidinones and its corresponding thioanalogs in refluxing ethanol. These are become popular in the world of synthetic organic chemistry due to their activities such as antibacterial, anti-viral, anti-inflametory. A series of the new 5-amido-4(phenyl)-6-methyl,3,4-dihydropyrimidin-2(1H)-ones have been synthesized by using the 5-ethoxycarbonyl-4(phenyl)-6-methyl,3,4-dihydropyrimidin-2(1H)-ones and the excess amount of the ammonia. The different compounds of this series can be synthesized by using one-pot multicomponent synthesis. The newly synthesized different amide derivatives of the 3,4, dihydropyrimidin-2(1H)-one were well monitor by using TLC plates. And these synthesized compounds were well characterized by 1H-NMR spectral studies. The results of such compound have been discussed in this paper. In the conclusion, we have developed a simple, quick a one pot multicomponent synthesis and characterization of different amide via Biginelli.
Keywords : Phosphoric acid , ammonia , one-pot synthesis, Biginelli reaction etc.
