Authors : D. Begde
Page Nos : 201-208
Description :
Abstract
Antimicrobial peptides (AMPs) are widespread in nature and are being employed by a diverse group of organisms, from bacteria to humans for exterminating microbial pathogens. Although having diverse origins, different structures and unique modes of action, all the AMPs share a common feature and that is, till date there are almost no reports suggesting the development of microbial resistance against these peptides. The present study uses a mathematical graph theoretical approach and the information from an updated AMP database-APD2 (http://aps.unmc.edu/AP/main.php)-to demonstrate the recurrence of some hydrophobic amino acid residues (motifs) within different classes of AMPs.
Key words: Sequences; Protein motifs; databases; biochemical networks
