Authors : D. B. Jadhao
Page Nos : 516-521
Description :
Malarial infections are still problem due to the adaption of the disease causing
parasites to existing preparations of 8 – aminoquinoline compounds. For instance
primaquine have been applied as chemotherapeutic agent for the treatment of malaria
diseases. Introduction of methyl group at 4th position and trifluorimethyl phenoxy group
at 5th position in primaquine modifies its biological activity. It is well known that the
antimalarial activity of 6-aminoquinoline compounds is similar to that of 8-aminoquinolines.
Thus newly synthesized compound has broad spectrum activity but
unfortunetly, it is too toxic to be used as a human medicine. So structural
modifications on such a nucleus are of great interest in the study of their biological
activities. Synthesis of metal complexes of 2-[(2-chloroquinoline-3-yl) methylene amino]
phenol [M(L)2] is one such structural modification studied. The structures of these
compounds have been established on the basis of conventional chemical
transformations and IR, NMR and mass spectral analysis.
All these compounds are prepared to investigate their antibacterial and
antifungal activities. It is observed that the above compound and their derivatives are
found to be antibacterial and antifungal in nature. Further antimalarial activity
investigations are in progress.