Issue Description


Authors : D. B. Jadhao

Page Nos : 516-521

Description :
Malarial infections are still problem due to the adaption of the disease causing parasites to existing preparations of 8 – aminoquinoline compounds. For instance primaquine have been applied as chemotherapeutic agent for the treatment of malaria diseases. Introduction of methyl group at 4th position and trifluorimethyl phenoxy group at 5th position in primaquine modifies its biological activity. It is well known that the antimalarial activity of 6-aminoquinoline compounds is similar to that of 8-aminoquinolines. Thus newly synthesized compound has broad spectrum activity but unfortunetly, it is too toxic to be used as a human medicine. So structural modifications on such a nucleus are of great interest in the study of their biological activities. Synthesis of metal complexes of 2-[(2-chloroquinoline-3-yl) methylene amino] phenol [M(L)2] is one such structural modification studied. The structures of these compounds have been established on the basis of conventional chemical transformations and IR, NMR and mass spectral analysis. All these compounds are prepared to investigate their antibacterial and antifungal activities. It is observed that the above compound and their derivatives are found to be antibacterial and antifungal in nature. Further antimalarial activity investigations are in progress.

Date of Online: 30 Jan 2014