Issue Description


Authors : S. Aswale1, B. Ramteke1, S. Aswale1, D. Tayade2

Page Nos : 7-13

Description :
Acetophenone and thiocarbamides molecules have their own identity in pharmaceutical, medicinal, agricultural and industrial chemistry. Heterocycles containing oxygen are mostly abundant among the naturally occurring heterocyclic compounds and are important and interest of various scientist from inter-disciplinary sciences. In view of utility of acetophenones and thiocarbamides in various fields and a part of research work presently being undertaken in these laboratories in the synthesis of newer type of heterocycles ,it was thought interesting to investigate the reaction of 2-hydroxy-3-nitro-5-methyl-alpha-bromoacetophenone with various thioureas in isopropanol medium to provide alternative or somewhat direct and easy route for the synthesis of 2-hydroxy-3-nitro-5-methyl-α-H/substituted thiocarbamidoacetophenone which are hitherto unknown. Structure determination and justification of newly synthesized compounds had been carried out on elemental analysis, chemical characteristics and through spectral data.

Date of Online: 30 Jan 2014