Issue Description


Authors : Ganvir K S

Page Nos : 96-100

Description :
Noristerat (Norethisterone Enanthate, NET-En) is used for the present study. This drug inhibits ovulation due to suppression of GnRH and pituitary gonadotrophins FSH & LH. On the basis of pharmacological – endocrinological background, these compounds have been used for fertility control in female. Noristerat has multiple site of action, as well as its primary site of action one still controversial. Considerable disagreement exists regarding the action of NET-En on anterior pituitary cell types. The paucity of information has led to reexamine this compound. The experiment was conducted on female palm squirrel during July-August i.e. at the end of breeding season. Female squirrels of experimental group received 0.5 mg/kg. B.W./week Noristerat for one month. Noristerat treated animals showed retarded growth of Graafian follicles. Except primary follicles other follicles showed degeneration. These degenerations were more evident in granulosa cells and oocytes. Ovary contained several atretic follicles. Corpus luteum disappeared from the ovary. Noristerat treated anterior pituitary showed no changes in growth hormone producing cells, but induced regressive changes such as reduction in number and size of cells & degranulation of FSH, LH & PRL cells. Direct action of Noristerat on ovary can be ruled out because if we assume that the Noristerat directly act on ovary and regress Graafian follicle and inhibit estrogen. Deficiency of estrogen expect hyperactivity of FSH cells which do not occur in the female squirrel. Deficiency of estrogen is responsible for the suppression of ovulation.

Date of Online: 30 Jan 2017