Authors : Ganvir K. S.
Page Nos : 42-44
Description :
Effects of LHRH-Agonist on thyroid-pituitary axis was investigated . The LHRH-Analogueused was LHRH-Agonist (Buserelin acetate).LHRH- Analogue have agonistic or antagonistic action .LHRH analogue block LHRH function, inhibit pituitary LH secretion and act as antagonist and this action is dose dependent.Perusal of literature has revealed that in the past , investigators have studied action of LHRH-Agonist on testis- pituitary axis ignoring its side effects on thyroid –pituitary axis.Further investigations are required to determine the side effects of this drug on thyroid and pituitary gland and its mechanism of action.The experiments were conducted during February and March when male squirrels were sexually active. Experimental animals received intramuscular injection of LHRH-agonist in two dose 0.2µg/animal /alternate day and 1.0 µg/animal /alternate day for 1 and 4 weeks respectively.
The present study on palm squirrel LHRH-Agonist induced degenerative changes in the thyroid epithelium, reduction in the amount of colloid of the follicle and regression of thyrotrophs (TSH cells) of anterior pituitary gland after both the treatment. Therefore it is concluded that regression of thyroid is via anterior pituitary gland.
Keywords : Thyroid – pituitary axis, LHRH-Agonist
